It is highly advised that you do not take multiple NSAIDs(Non-steroidal anti-inflammatory drugs) at one time. Both Mobic and Ibuprofen are NSAIDs, and combining them can have adverse effects such. really not safe to take together but ibuprofen is a ISAID AND mobic is a coxii only 2 drugs for antiinflamatory celebrex,and mobic are the only two in this group,all others are nsaid's but the work the same course and can cause serious damage to your stomach.nice about celebrex and mobic is they stay in your system much longer and you don't. I was having horrible tooth pain with abcess. Dr. prescribed Meloxicam. No, it doesn`t get you high but it does relieve the pain. It`s nearly impossible nowadays for a doctor to prescribe opiates such as Vicodin, and if they do prescribe it, they only prescribe a few, like 10-20. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Jacobson on can i take advil with meloxicam: These medications are both antiinflammatory and should never be used together. Meloxicam can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). How to use Mobic. Read the Medication Guide provided by your pharmacist before you start taking meloxicam and each time you get a refill. If you have any questions, ask your doctor or pharmacist. You can take meloxicam and Tylenol together but I would not recommend that you take meloxicam and Aleve together. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Grin on can i take meloxicam and ibuprofen: Adequate pain control often requires multiple medications. Oxycodone is often combined with anti-inflammatory agents as naproxen. Taking 2 agents with different modes of action gives better results with lower side effects. Ibuprofen vs. meloxicam (Mobic) quick comparison of differences Ibuprofen ( Advil , Motrin , and others) and meloxicam ( Mobic ) are nonsteroidal anti-inflammatory drugs ( NSAIDs ) used for the management of mild to moderate pain , fever , and inflammation. , make my heartbeat and bp go crazy. i can take ibuprofen, motrin.nurse told me to try the mobic, and if i have any problems, to let them know. i really don't want to take a chance on it raising my blood pressure and heart rate; besides, i don't want to pay for a med i may not be able to take (and she said they don't have any samples).